<i>DNAJB1–PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma
Significance Efforts to understand and treat fibrolamellar hepatocellular carcinoma (FL-HCC) have been confounded by a lack of models that accurately reflect the genetics and biology of the disease. Here we demonstrate that the Dnajb1–Prkaca gene fusion drives tumorigenesis in mice, and that fusion...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2017
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| Online Access: | https://doi.org/10.1073/pnas.1716483114 https://www.pnas.org/content/pnas/114/50/13076.full.pdf |
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