Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

Neurodevelopmental disorders offer insight into synaptic mechanisms. To unbiasedly uncover these mechanisms, we studied the 22q11.2 syndrome, a recurrent copy number variant, which is the highest schizophrenia genetic risk factor. We quantified the proteomes of 22q11.2 mutant human fibroblasts from...

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Hlavní autoři: Avanti Gokhale, Cortnie Hartwig, A. Freeman, Julia L. Bassell, Stephanie A. Zlatic, Christie Sapp Savas, Trishna Vadlamudi, Farida Abudulai, Tyler T. Pham, Amanda Crocker, Erica Werner, Zhexing Wen, Gabriela M. Repetto, Joseph A. Gogos, Steven M. Claypool, Jennifer K. Forsyth, Carrie E. Bearden, Jill R. Glausier, David A. Lewis, Nicholas T. Seyfried, Jennifer Q. Kwong, Victor Faúndez
Médium: Artigo
Jazyk:angličtina
Vydáno: 2019
On-line přístup:https://doi.org/10.1523/jneurosci.1983-18.2019
https://www.jneurosci.org/content/jneuro/39/18/3561.full.pdf
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https://doi.org/10.1523/jneurosci.1983-18.2019
https://www.jneurosci.org/content/jneuro/39/18/3561.full.pdf

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