Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

Large copy number variants (CNVs) in the human genome are strongly associated with common neurodevelopmental, neuropsychiatric disorders such as schizophrenia and autism. Here we report on the epigenomic effects of the prominent large deletion CNVs on chromosome 22q11.2 and on chromosome 1q21.1. We...

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Hoofdauteurs: Xianglong Zhang, Ying Zhang, Xiaowei Zhu, Carolin Purmann, Michael S. Haney, Thomas Ward, Arineh Khechaduri, Jie Yao, Sherman M. Weissman, Alexander E. Urban
Formaat: Artigo
Taal:Engels
Gepubliceerd in: 2018
Online toegang:https://doi.org/10.1038/s41467-018-07766-x
https://www.nature.com/articles/s41467-018-07766-x.pdf
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