An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
The majority of individuals with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) exhibit neuronal cytoplasmic inclusions rich in the RNA binding protein TDP43. Even so, the relation between the RNA binding properties of TDP43 and neurodegeneration remains obscure. Here, we show...
Enregistré dans:
| Auteurs principaux: | , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2019
|
| Accès en ligne: | https://doi.org/10.1016/j.celrep.2019.03.093 https://www.cell.com/article/S2211124719304322/pdf |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|