Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities

Introduction: Cancer genome sequencing studies have discovered mutations in members of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly 25% of human cancers. The SWI/SNF complex, first discovered in S. cerevisiae, shows strong conservation from yeast to Drosophila...

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Bibliografiske detaljer
Main Authors: Krystal A. Orlando, Vinh Nguyen, Jesse R. Raab, Tara Walhart, Bernard E. Weissman
Format: Revisão
Sprog:engelsk
Udgivet: 2019
Online adgang:https://doi.org/10.1080/14737140.2019.1605905
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