Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

Abstract Despite recent advances in the use of immunotherapy, only a minority of patients with small cell lung cancer (SCLC) respond to immune checkpoint blockade (ICB). Here, we show that targeting the DNA damage response (DDR) proteins PARP and checkpoint kinase 1 (CHK1) significantly increased pr...

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Main Authors: Triparna Sen, B. Leticia Rodriguez, Limo Chen, Carminia Maria Della Corte, Naoto Morikawa, Junya Fujimoto, Sandra Cristea, Thuyen Nguyen, Lixia Diao, Lerong Li, You-Hong Fan, Yongbin Yang, Jing Wang, Bonnie S. Glisson, Ignacio I. Wistuba, Julien Sage, John V. Heymach, Don L. Gibbons, Lauren A. Byers
Formato: Artigo
Idioma:inglés
Publicado: 2019
Acceso en liña:https://doi.org/10.1158/2159-8290.cd-18-1020
https://cancerdiscovery.aacrjournals.org/content/candisc/9/5/646.full.pdf
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https://doi.org/10.1158/2159-8290.cd-18-1020
https://cancerdiscovery.aacrjournals.org/content/candisc/9/5/646.full.pdf

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