17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Abstract Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexes. 17‐α estradiol (17aE2), a less feminizing structural isomer of 17‐β estradiol, produces lifespan extension only in male mice, suggesting a sexually dimorphic mechanism of lifespan regulati...

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Main Authors: Michael Garratt, Danielle C. Leander, Kaitlyn Pifer, Brian D. Bower, Jonathan J. Herrera, Sharlene M. Day, Oliver Fiehn, Susan V. Brooks, Richard A. Miller
Format: Artigo
Jezik:angleščina
Izdano: 2019
Online dostop:https://doi.org/10.1111/acel.12920
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12920
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