17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Abstract Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ between sexes. 17‐α estradiol (17aE2), a less feminizing structural isomer of 17‐β estradiol, produces lifespan extension only in male mice, suggesting a sexually dimorphic mechanism of lifespan regulati...

詳細記述

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書誌詳細
主要な著者: Michael Garratt, Danielle C. Leander, Kaitlyn Pifer, Brian D. Bower, Jonathan J. Herrera, Sharlene M. Day, Oliver Fiehn, Susan V. Brooks, Richard A. Miller
フォーマット: Artigo
言語:英語
出版事項: 2019
オンライン・アクセス:https://doi.org/10.1111/acel.12920
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12920
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