Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1
Highlights•In mouse oocytes, an excess of cyclin B1 preserves CDK1 activity•A motif in non-CDK1-bound cyclin B1 confers preferential APC/C targeting•Non-CDK1-bound cyclin B1 is gradually destroyed before CDK1-bound cyclin B1•Prolonged CDK1 activity assists the spindle checkpoint and prevents aneuplo...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2019
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| Accés en línia: | https://doi.org/10.1016/j.devcel.2019.01.008 |
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