Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by widespread fibrosis, microangiopathy and autoantibodies. Follicular helper T (Tfh) cells CD4 + CXCR5 + PD-1 + cooperate with B lymphocytes to induce the differentiation of plasmocytes secreting immunoglobulins (Ig). Circul...

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Main Authors: Laure Ricard, Vincent Jachiet, Florent Malard, Yishan Ye, Nicolas Stocker, Sébastien Rivière, P. Senet, J.‐B. Monfort, O. Fain, Mohamad Mohty, Béatrice Gaugler, A. Mékinian
Format: Artigo
Jezik:angleščina
Izdano: 2019
Online dostop:https://doi.org/10.1136/annrheumdis-2018-214382
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Internet

https://doi.org/10.1136/annrheumdis-2018-214382

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