Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by widespread fibrosis, microangiopathy and autoantibodies. Follicular helper T (Tfh) cells CD4 + CXCR5 + PD-1 + cooperate with B lymphocytes to induce the differentiation of plasmocytes secreting immunoglobulins (Ig). Circul...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Acesso em linha: | https://doi.org/10.1136/annrheumdis-2018-214382 |
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