Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by widespread fibrosis, microangiopathy and autoantibodies. Follicular helper T (Tfh) cells CD4 + CXCR5 + PD-1 + cooperate with B lymphocytes to induce the differentiation of plasmocytes secreting immunoglobulins (Ig). Circul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Laure Ricard, Vincent Jachiet, Florent Malard, Yishan Ye, Nicolas Stocker, Sébastien Rivière, P. Senet, J.‐B. Monfort, O. Fain, Mohamad Mohty, Béatrice Gaugler, A. Mékinian
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2019
Mynediad Ar-lein:https://doi.org/10.1136/annrheumdis-2018-214382
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

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https://doi.org/10.1136/annrheumdis-2018-214382

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