TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

The telomeric protein TRF2 is overexpressed in several human malignancies and contributes to tumorigenesis even though the molecular mechanism is not completely understood. By using a high-throughput approach based on the multiplexed Luminex X-MAP technology, we demonstrated that TRF2 dramatically a...

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Autores principales: Pasquale Zizza, Roberto Dinami, Manuela Porru, Chiara Cingolani, Erica Salvati, Angela Rizzo, Carmen D’Angelo, Eleonora Petti, Carla Azzurra Amoreo, Marcella Mottolese, Isabella Sperduti, Angela Chambery, Rosita Russo, Paola Ostano, Giovanna Chiorino, Giovanni Blandino, Andrea Sacconi, Julien Cherfils‐Vicini, Carlo Leonetti, Éric Gilson, Annamaria Biroccio
Formato: Artigo
Lenguaje:inglés
Publicado: 2019
Acceso en línea:https://doi.org/10.1093/nar/gkz041
https://academic.oup.com/nar/article-pdf/47/7/3365/28467596/gkz041.pdf
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