Loss-of-Function <i>ABCC8</i> Mutations in Pulmonary Arterial Hypertension

Loss-of-Function <i>ABCC8</i> Mutations in Pulmonary Arterial Hypertension

Background: In pulmonary arterial hypertension (PAH), pathological changes in pulmonary arterioles progressively raise pulmonary artery pressure and increase pulmonary vascular resistance, leading to right heart failure and high mortality rates. Recently, the first potassium channelopathy in PAH, be...

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Auteurs principaux: Michael S. Bohnen, Lijiang Ma, Na Zhu, Hongjian Qi, Conor McClenaghan, Claudia Gonzaga‐Jauregui, Frederick E. Dewey, John D. Overton, Jeffrey G. Reid, Alan R. Shuldiner, Aris Baras, Kevin J. Sampson, Marta Bleda, Charaka Hadinnapola, Matthias Haimel, Harm Jan Bogaard, Colin Church, Gerry Coghlan, Paul A. Corris, Mélanie Eyries, J. Simon R. Gibbs, Barbara Girerd, Arjan C. Houweling, Marc Humbert, Christophe Guignabert, David G. Kiely, Allan Lawrie, Rob V. Mackenzie Ross, Jennifer M. Martin, David Montani, Andrew J. Peacock, Joanna Pepke‐Żaba, Florent Soubrier, Jay Suntharalingam, Mark Toshner, Carmen Treacy, Richard C. Trembath, Anton Vonk Noordegraaf, John Wharton, Martin R. Wilkins, Stephen J. Wort, Katherine Yates, Stefan Gräf, Nicholas W. Morrell, Usha Krishnan, Erika B. Rosenzweig, Yufeng Shen, Colin G. Nichols, Robert S. Kass, Wendy K. Chung
Format: Artigo
Langue:anglais
Publié: 2018
Accès en ligne:https://doi.org/10.1161/circgen.118.002087
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https://doi.org/10.1161/circgen.118.002087

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