Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy.A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chroni...

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Hlavní autoři: Marco Cordani, Giovanna Butera, Ilaria Dando, Margalida Torrens‐Mas, Elena Butturini, Raffaella Pacchiana, Elisa Oppici, Chiara Cavallini, Sara Gasperini, Nicola Tamassia, Mercedes Nadal‐Serrano, Michela Coan, Davide Rossi, Gianluca Gaïdano, Michele Caraglia, Sofia Mariotto, Riccardo Spizzo, Pilar Roca, Jordi Oliver, Maria Teresa Scupoli, Massimo Donadelli
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1038/s41416-018-0288-2
https://www.nature.com/articles/s41416-018-0288-2.pdf
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https://doi.org/10.1038/s41416-018-0288-2
https://www.nature.com/articles/s41416-018-0288-2.pdf

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