Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis

Abstract The cell adhesion molecule P‐selectin plays a key role in the pathogenesis of a vaso‐occlusive crisis (VOC) in patients with sickle cell disease (SCD). In the double‐blind, placebo‐controlled phase 2 SUSTAIN study, crizanlizumab (humanized, anti‐P‐selectin monoclonal antibody) 5 mg/kg signi...

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Huvudupphovsmän: Abdullah Kutlar, Julie Kanter, Darla Liles, Ofelia Álvarez, Rodolfo Delfini Cançado, João Ricardo Friedrisch, Jennifer Knight‐Madden, Andreas Bruederle, Michael Shi, Zewen Zhu, Kenneth I. Ataga
Materialtyp: Artigo
Språk:engelska
Publicerad: 2018
Länkar:https://doi.org/10.1002/ajh.25308
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.25308
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