Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes

Recently, μ-opioid receptor (MOR), one of the well-known Gi-protein coupled receptors (Gi-GPCR), was reported to be highly expressed in the hippocampal astrocytes. However, the role of astrocytic MOR has not been investigated. Here we report that activation of astrocytic MOR by [D-Ala2,N-MePhe4,Gly-...

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Main Authors: Dong Ho Woo, Jin Young Bae, Min‐Ho Nam, Heeyoung An, Yeon Ha Ju, Joungha Won, Jae Hyouk Choi, Eun Mi Hwang, K.S. Han, Yong Chul Bae, C. Justin Lee
格式: Artigo
語言:英语
出版: 2018
在線閱讀:https://doi.org/10.3389/fncel.2018.00319
https://www.frontiersin.org/articles/10.3389/fncel.2018.00319/pdf
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