Attenuation of Microbiotal Dysbiosis and Hypertension in a <i>CRISPR/Cas9</i> Gene Ablation Rat Model of <i>GPER1</i>
G-protein–coupled estrogen receptor, Gper1 , has been implicated in cardiovascular disease, but its mechanistic role in blood pressure control is poorly understood. Here, we demonstrate that genetically salt-sensitive hypertensive rats with complete genomic excision of Gper1 by a multiplexed guide R...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2018
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| On-line přístup: | https://doi.org/10.1161/hypertensionaha.118.11175 |
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