Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases

Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases

Exposure to vinclozolin has been shown to induce the epigenetic transgenerational inheritance of increased susceptibility to disease, and to induce transgenerational changes to the epigenome. In the current study, gestating F0 generation rats were exposed to vinclozolin, and the subsequent F1, F2 an...

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Hlavní autoři: Eric Nilsson, Stephanie E. King, Margaux McBirney, Deepika Kubsad, Michelle Pappalardo, Daniel Beck, Ingrid Sadler‐Riggleman, Michael K. Skinner
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1371/journal.pone.0202662
https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0202662/1/pone.0202662.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T140251Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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https://doi.org/10.1371/journal.pone.0202662
https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0202662/1/pone.0202662.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T140251Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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