High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms

High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms

Human cytomegalovirus (HCMV) is an important pathogen with multiple immune evasion strategies, including virally facilitated degradation of host antiviral restriction factors. Here, we describe a multiplexed approach to discover proteins with innate immune function on the basis of active degradation...

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Main Authors: Katie Nightingale, Kai‐Min Lin, Benjamin J. Ravenhill, Colin Davies, Luís Nobre, Ceri A. Fielding, Eva Růčková, Alice Fletcher-Etherington, Lior Soday, Hester Nichols, Daniel Sugrue, Eddie C. Y. Wang, Pablo Moreno, Yagnesh Umrania, Edward L. Huttlin, Robin Antrobus, Andrew J. Davison, Gavin W. G. Wilkinson, Richard J. Stanton, Peter Tomašec, Michael P. Weekes
Formato: Artigo
Idioma:inglés
Publicado: 2018
Acceso en liña:https://doi.org/10.1016/j.chom.2018.07.011
https://www.cell.com/article/S1931312818303810/pdf
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