DUSP6 mediates T cell receptor-engaged glycolysis and restrains T <sub>FH</sub> cell differentiation
Significance Naive T cells at quiescent state utilize mitochondrial respiration to generate ATP. In response to antigen, activated T cells through T cell receptor (TCR) and CD28 differentiate to T H 1, T H 2, or T H 17 effector cells with an induction of aerobic glycolysis. Here, we demonstrate a ro...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2018
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| Online Access: | https://doi.org/10.1073/pnas.1800076115 https://www.pnas.org/content/pnas/115/34/E8027.full.pdf |
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