Structural insights into ubiquitin phosphorylation by PINK1

Structural insights into ubiquitin phosphorylation by PINK1

Abstract Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain...

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Main Authors: Kei Okatsu, Yusuke Sato, Koji Yamano, Noriyuki Matsuda, Lumi Negishi, Akiko Takahashi, Atsushi Yamagata, Sakurako Goto‐Ito, Masaki Mishima, Yutaka Ito, Toshihiko Oka, Keiji Tanaka, Shuya Fukai
Format: Artigo
Jezik:angleščina
Izdano: 2018
Online dostop:https://doi.org/10.1038/s41598-018-28656-8
https://www.nature.com/articles/s41598-018-28656-8.pdf
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https://doi.org/10.1038/s41598-018-28656-8
https://www.nature.com/articles/s41598-018-28656-8.pdf

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