Structural insights into ubiquitin phosphorylation by PINK1

Structural insights into ubiquitin phosphorylation by PINK1

Abstract Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Kei Okatsu, Yusuke Sato, Koji Yamano, Noriyuki Matsuda, Lumi Negishi, Akiko Takahashi, Atsushi Yamagata, Sakurako Goto‐Ito, Masaki Mishima, Yutaka Ito, Toshihiko Oka, Keiji Tanaka, Shuya Fukai
Hōputu: Artigo
Reo:Ingarihi
I whakaputaina: 2018
Urunga tuihono:https://doi.org/10.1038/s41598-018-28656-8
https://www.nature.com/articles/s41598-018-28656-8.pdf
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Ipurangi

https://doi.org/10.1038/s41598-018-28656-8
https://www.nature.com/articles/s41598-018-28656-8.pdf

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