Structural insights into ubiquitin phosphorylation by PINK1
Abstract Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain...
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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2018
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| Accès en ligne: | https://doi.org/10.1038/s41598-018-28656-8 https://www.nature.com/articles/s41598-018-28656-8.pdf |
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