Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs
Abstract Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell–derived IFN-I is required to recruit BATF3-dependent dendritic cells (DC) to poorly immunoge...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2018
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| 在线阅读: | https://doi.org/10.1158/2326-6066.cir-17-0581 https://cancerimmunolres.aacrjournals.org/content/canimm/6/8/910.full.pdf |
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