An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors

An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors

By leveraging tumorgraft (patient-derived xenograft) RNA-sequencing data, we developed an empirical approach, DisHet, to dissect the tumor microenvironment (eTME). We found that 65% of previously defined immune signature genes are not abundantly expressed in renal cell carcinoma (RCC) and identified...

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Main Authors: Tao Wang, Rong Lü, Payal Kapur, Bijay S. Jaiswal, Raquibul Hannan, Ze Zhang, Iván Pedrosa, Jason J. Luke, He Zhang, Leonard D. Goldstein, Qurratulain Yousuf, Yi-Feng Gu, Tiffani McKenzie, Allison Joyce, Min S. Kim, Xinlei Wang, Danni Luo, Oreoluwa Onabolu, Christina Stevens, Zhiqun Xie, Mingyi Chen, Alexander Filatenkov, José Torrealba, Xin Luo, Wenbin Guo, Jingxuan He, Eric Stawiski, Zora Modrušan, Steffen Durinck, Somasekar Seshagiri, James Brugarolas
Formato: Artigo
Idioma:inglés
Publicado: 2018
Acceso en liña:https://doi.org/10.1158/2159-8290.cd-17-1246
https://cancerdiscovery.aacrjournals.org/content/candisc/8/9/1142.full.pdf
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https://doi.org/10.1158/2159-8290.cd-17-1246
https://cancerdiscovery.aacrjournals.org/content/candisc/8/9/1142.full.pdf

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