Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer

Patient-derived xenograft (PDX) models with definite molecular signature are attractive preclinical models for development of novel targeted drugs. Here, we profiled and explored potential therapeutic targets based on characterized PDX models for advanced gastric cancer (AGC). The genomic variation...

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Hlavní autoři: Zuhua Chen, Wenwen Huang, Tiantian Tian, Wanchun Zang, Jingyuan Wang, Zhentao Liu, Zhongwu Li, Yumei Lai, Zhi Jiang, Jing Gao, Lin Shen
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1186/s13045-018-0563-y
https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-018-0563-y
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