Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
Abstract Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP + to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathio...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2018
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| 在线阅读: | https://doi.org/10.1038/s41598-018-23436-w https://www.nature.com/articles/s41598-018-23436-w.pdf |
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