Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

Abstract Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP + to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathio...

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Hlavní autoři: Karessa White, Mi‐Jung Kim, Chul Ju Han, Hyo‐Jin Park, Dalian Ding, Kevin N. Boyd, Logan C. Walker, Paul J. Linser, Zaimary Meneses, Cole Slade, Jonathan J. Hirst, Katherine E. Santostefano, Naohiro Terada, Takuya Miyakawa, Masaru Tanokura, Richard Salvi, Shinichi Someya
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1038/s41598-018-23436-w
https://www.nature.com/articles/s41598-018-23436-w.pdf
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https://doi.org/10.1038/s41598-018-23436-w
https://www.nature.com/articles/s41598-018-23436-w.pdf

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