Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents

Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents

Neuroinflammation appears to contribute to neurotoxicity observed with heavy alcohol consumption. To assess whether chronic alcohol results in neuroinflammation we used PET and [11C]PBR28, a ligand that binds to the 18-kDa translocator protein (TSPO), to compare participants with an alcohol use diso...

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Main Authors: Sung Won Kim, Corinde E. Wiers, Ryan E. Tyler, Ehsan Shokri‐Kojori, Yeon Joo Jang, Amna Zehra, Clara Freeman, Veronica Ramirez, Elsa Lindgren, Gregg Miller, Elizabeth Cabrera, Tyler Stodden, Min Guo, Şükrü Barış Demiral, Nancy Diazgranados, Luke Park, Jeih‐San Liow, Victor W. Pike, Cheryl L. Morse, Leandro F. Vendruscolo, Robert B. Innis, George F. Koob, Dardo Tomasi, Gene‐Jack Wang, Nora D. Volkow
Format: Artigo
Language:English
Published: 2018
Online Access:https://doi.org/10.1038/s41386-018-0085-x
https://www.nature.com/articles/s41386-018-0085-x.pdf
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https://doi.org/10.1038/s41386-018-0085-x
https://www.nature.com/articles/s41386-018-0085-x.pdf

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