Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits

Modulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating G-protein-coupled receptors (GPCRs) that control the production of second messengers directly impacting cellular physiology. How numerous GPCRs integrate n...

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Hlavní autoři: Brian S. Muntean, Stefano Zucca, Courtney MacMullen, Maria Dao, Caitlin Johnston, Hideki Iwamoto, Randy Blakely, Ronald L. Davis, Kirill A. Martemyanov
Médium: Artigo
Jazyk:angličtina
Vydáno: 2018
On-line přístup:https://doi.org/10.1016/j.celrep.2017.12.022
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https://doi.org/10.1016/j.celrep.2017.12.022

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