Lower temperatures reduce type I interferon activity and promote alphaviral arthritis
Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthrop...
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| Main Authors: | , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2017
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| 在線閱讀: | https://doi.org/10.1371/journal.ppat.1006788 https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006788&type=printable |
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