Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthrop...

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Príomhchruthaitheoirí: Natalie A. Prow, Bing Tang, Joy Gardner, Thuy T. Le, Adam Taylor, Yee Suan Poo, Eri Nakayama, Thiago Dominguez Crespo Hirata, Helder I. Nakaya, Andrii Slonchak, Pamela Mukhopadhyay, Suresh Mahalingam, Wayne A. Schroder, William B. Klimstra, Andreas Suhrbier
Formáid: Artigo
Teanga:Béarla
Foilsithe / Cruthaithe: 2017
Rochtain ar líne:https://doi.org/10.1371/journal.ppat.1006788
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006788&type=printable
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Ar líne

https://doi.org/10.1371/journal.ppat.1006788
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006788&type=printable

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