Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthrop...

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Bibliographic Details
Main Authors: Natalie A. Prow, Bing Tang, Joy Gardner, Thuy T. Le, Adam Taylor, Yee Suan Poo, Eri Nakayama, Thiago Dominguez Crespo Hirata, Helder I. Nakaya, Andrii Slonchak, Pamela Mukhopadhyay, Suresh Mahalingam, Wayne A. Schroder, William B. Klimstra, Andreas Suhrbier
Format: Artigo
Language:English
Published: 2017
Online Access:https://doi.org/10.1371/journal.ppat.1006788
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006788&type=printable
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