A hypertension-associated mitochondrial DNA mutation introduces an m1G37 modification into tRNAMet, altering its structure and function
Defective nucleotide modifications of mitochondrial tRNAs have been associated with several human diseases, but their pathophysiology remains poorly understood. In this report, we investigated the pathogenic molecular mechanism underlying a hypertension-associated 4435A→G mutation in mitochondrial t...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2017
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| 在线阅读: | https://doi.org/10.1074/jbc.ra117.000317 http://www.jbc.org/article/S0021925820391420/pdf |
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