CD1b-restricted GEM T cell responses are modulated by<i>Mycobacterium tuberculosis</i>mycolic acid meromycolate chains

CD1b-restricted GEM T cell responses are modulated by<i>Mycobacterium tuberculosis</i>mycolic acid meromycolate chains

Significance Tuberculosis is a major global pandemic responsible for more deaths than any other infectious disease, yet no effective vaccine exists. Here, we demonstrate CD1b expression within human tuberculous granulomas, supporting a role for CD1b lipid antigen presentation in host immunity to inf...

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Main Authors: Andrew Chancellor, Anna S. Tocheva, Chris Cave-Ayland, Liku B. Tezera, Andrew White, Juma’a R. Al Dulayymi, John S. Bridgeman, Ivo Tews, Susan Wilson, Nikolai M. Lissin, Marc Tebruegge, Ben G. Marshall, Sally Sharpe, Tim Elliott, Chris‐Kriton Skylaris, Jonathan W. Essex, Mark S. Baird, Stephan D. Gadola, Paul Elkington, Salah Mansour
Format: Artigo
Language:English
Published: 2017
Online Access:https://doi.org/10.1073/pnas.1708252114
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https://doi.org/10.1073/pnas.1708252114

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