NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities of lung cancer cells in vitro and in vivo. Depletion of NatD suppresses the epithelial-to-mes...

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Main Authors: Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, David C.S. Huang, C. David Allis, Renxiang Tan, Changjiang Zeng, Jiwu Wei, Quan Zhao
Format: Artigo
Language:English
Published: 2017
Online Access:https://doi.org/10.1038/s41467-017-00988-5
https://www.nature.com/articles/s41467-017-00988-5.pdf
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https://doi.org/10.1038/s41467-017-00988-5
https://www.nature.com/articles/s41467-017-00988-5.pdf

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