Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Necrosis is a hallmark of glioblastoma (GBM) and is responsible for poor prognosis and resistance to conventional therapies. However, the molecular mechanisms underlying necrotic microenvironment-induced malignancy of GBM have not been elucidated. Here, we report that transglutaminase 2 (TGM2) is up...

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Main Authors: Jinlong Yin, Young Taek Oh, Jeong-Yub Kim, Sung Soo Kim, Eunji Choi, Tae Hoon Kim, Jun Hee Hong, Nakho Chang, Hee Jin Cho, K. Jason, Jeong Cheol Kim, Hyung Joon Kwon, Saewhan Park, Weiwei Lin, Ichiro Nakano, Ho‐Shin Gwak, Heon Yoo, Seung‐Hoon Lee, Jeongwu Lee, Jong Heon Kim, Soo-Youl Kim, Do‐Hyun Nam, Myung Jin Park, Jong Bae Park
Format: Artigo
Language:English
Published: 2017
Online Access:https://doi.org/10.1158/0008-5472.can-17-0388
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https://doi.org/10.1158/0008-5472.can-17-0388

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