Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable "base editing" system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase, up to 28% of site-specific single-...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2017
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| Online Access: | https://doi.org/10.1038/s41467-017-00175-6 https://www.nature.com/articles/s41467-017-00175-6.pdf |
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