Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence variants that truncate the

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Main Authors:	Akihiro Nomura, Hong‐Hee Won, Amit V. Khera, Fumihiko Takeuchi, Kaoru Ito, Shane McCarthy, Connor A. Emdin, Derek Klarin, Pradeep Natarajan, Seyedeh M. Zekavat, Namrata Gupta, Gina M. Peloso, Ingrid B. Borecki, Tanya M. Teslovich, Rosanna Asselta, Stefano Duga, Piera Angelica Merlini, Adolfo Correa, Thorsten Kessler, James G. Wilson, Matthew J. Bown, Alistair S. Hall, Peter S. Braund, David J. Carey, Michael F. Murray, H. Lester Kirchner, Joseph B. Leader, Daniel R. Lavage, J. Neil Manus, Dustin N. Hartze, Nilesh J. Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosúa, Ruth McPherson, Martin Farrall, Hugh Watkins, Jyh‐Ming Jimmy Juang, Chao A. Hsiung, Shih-Yi Lin, Jun‐Sing Wang, Hayato Tada, Masa‐aki Kawashiri, Akihiro Inazu, Masakazu Yamagishi, Tomohiro Katsuya, Eitaro Nakashima, Masahiro Nakatochi, Ken Yamamoto, Mitsuhiro Yokota, Yukihide Momozawa, Jerome I. Rotter, Eric S. Lander, Daniel J. Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen J. Willer, Gonçalo R. Abecasis, Danish Saleheen, Michiaki Kubo, Norihiro Kato, Yii‐Der Ida Chen, Frederick E. Dewey, Sekar Kathiresan
Formato:	Revisão
Idioma:	Inglês
Publicado em:	2017
Acesso em linha:	https://doi.org/10.1161/circresaha.117.311145 https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.117.311145
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https://doi.org/10.1161/circresaha.117.311145
https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.117.311145