Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the pro-survival chemokine CXCL12 with its cognate receptor CXCR4 induces...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2017
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| 在線閱讀: | https://doi.org/10.1186/s13045-017-0435-x https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0435-x |
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