Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the pro-survival chemokine CXCL12 with its cognate receptor CXCR4 induces...

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Main Authors: Manoj Kumar Kashyap, Carlos I. Amaya-Chanaga, Deepak Kumar, Brett H. Simmons, Nanni Huser, Yin Gu, Max Hallin, Kevin C. Lindquist, Rolla Yafawi, Michael Y. Choi, Amine Ale-Ali, Laura Z. Rassenti, Cathy Zhang, Shu‐Hui Liu, Tod Smeal, Valeria R. Fantin, Thomas J. Kipps, Flavia Pernasetti, Januario E. Castro
Format: Artigo
Language:English
Published: 2017
Online Access:https://doi.org/10.1186/s13045-017-0435-x
https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0435-x
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https://doi.org/10.1186/s13045-017-0435-x
https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-017-0435-x

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