Tracking the Evolution of Non–Small-Cell Lung Cancer

Tracking the Evolution of Non–Small-Cell Lung Cancer

Background Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome and to determine the clona...

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Main Authors: Mariam Jamal‐Hanjani, Gareth A. Wilson, Nicholas McGranahan, Nicolai J. Birkbak, Thomas B.K. Watkins, Selvaraju Veeriah, Seema Shafi, Diana Johnson, Richard Mitter, Rachel Rosenthal, Max Salm, Stuart Horswell, Mickael Escudero, Nik Matthews, Andrew Rowan, Tim Chambers, David A. Moore, Samra Turajlic, Hang Xu, Siow Ming Lee, Martin Förster, Tanya Ahmad, Crispin T. Hiley, Christopher Abbosh, Mary Falzon, Elaine Borg, Teresa Marafioti, David Lawrence, Sophia Ward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M. Janes, Ricky M. Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Rajesh Shah, Leena Dennis Joseph, Anne Marie Quinn, Philip Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, M. Nicolson, Hardy Remmen, Keith M. Kerr, Mahendran Chetty, Lesley Gomersall, Dean A. Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, J.F. Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Stefan C. Dentro, Philippe Tanière, Brendan O’Sullivan, Helen L. Lowe, John A. Hartley, Natasha Iles, Harriet Bell, Yenting Ngai, Jacqui Shaw, Javier Herrero, Zoltán Szállási, Roland F. Schwarz, Aengus Stewart, Sergio A. Quezada, John Le Quesne, Peter Van Loo, Caroline Dive, Allan Hackshaw, Charles Swanton
Format: Artigo
Language:English
Published: 2017
Online Access:https://doi.org/10.1056/nejmoa1616288
https://www.nejm.org/doi/pdf/10.1056/NEJMoa1616288?articleTools=true
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https://doi.org/10.1056/nejmoa1616288
https://www.nejm.org/doi/pdf/10.1056/NEJMoa1616288?articleTools=true

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