Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation

Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contras...

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Hlavní autoři: Craig S. Schneider, Qingguo Xu, Nicholas J. Boylan, Jane Chisholm, Benjamin C. Tang, Benjamin S. Schuster, Andreas Henning, Laura M. Ensign, Ethan Lee, Pichet Adstamongkonkul, Brian W. Simons, Sho-Yu S. Wang, Xiaoqun Gong, Tao Yu, Michael Boyle, Jung Soo Suk, Justin Hanes
Médium: Artigo
Jazyk:angličtina
Vydáno: 2017
On-line přístup:https://doi.org/10.1126/sciadv.1601556
https://advances.sciencemag.org/content/advances/3/4/e1601556.full.pdf
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