In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites
In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of these sites is determined by the sequence-specific DNA binding domain of the PRDM9 histone methyl transferase. Here, we performed an extensiv...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2017
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| 在线阅读: | https://doi.org/10.1101/gr.217240.116 http://genome.cshlp.org/content/27/4/580.full.pdf |
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