In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of these sites is determined by the sequence-specific DNA binding domain of the PRDM9 histone methyl transferase. Here, we performed an extensiv...

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Библиографические подробности
Главные авторы:	Corinne Grey, Julie A. J. Clément, Jérôme Buard, Benjamin Leblanc, Marta Gut, Laurent Duret, Bernard de Massy
Формат:	Artigo
Язык:	английский
Опубликовано:	2017
Online-ссылка:	https://doi.org/10.1101/gr.217240.116 http://genome.cshlp.org/content/27/4/580.full.pdf
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