In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of these sites is determined by the sequence-specific DNA binding domain of the PRDM9 histone methyl transferase. Here, we performed an extensiv...

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Bibliografiske detaljer
Main Authors:	Corinne Grey, Julie A. J. Clément, Jérôme Buard, Benjamin Leblanc, Marta Gut, Laurent Duret, Bernard de Massy
Format:	Artigo
Sprog:	engelsk
Udgivet:	2017
Online adgang:	https://doi.org/10.1101/gr.217240.116 http://genome.cshlp.org/content/27/4/580.full.pdf
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Lignende værker

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites
af: Grey, Corinne, et al.
Udgivet: (2017)

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice
af: Frédéric Baudat, et al.
Udgivet: (2010)

PRDM9, a driver of the genetic map
af: Grey, Corinne, et al.
Udgivet: (2018)

PRDM9, a driver of the genetic map
af: Corinne Grey, et al.
Udgivet: (2018)

PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites
af: Boubou Diagouraga, et al.
Udgivet: (2018)

PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
af: Imai, Yukiko, et al.
Udgivet: (2020)

PRDM9 is a Major Determinant of Meiotic Recombination Hotspots in humans and mice
af: Baudat, F., et al.
Udgivet: (2009)

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish
af: Marie Raynaud, et al.
Udgivet: (2025)

Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination
af: Grey, Corinne, et al.
Udgivet: (2011)

Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination
af: Corinne Grey, et al.
Udgivet: (2011)

Diversity of Prdm9 Zinc Finger Array in Wild Mice Unravels New Facets of the Evolutionary Turnover of this Coding Minisatellite
af: Buard, Jérôme, et al.
Udgivet: (2014)

Diversity of Prdm9 Zinc Finger Array in Wild Mice Unravels New Facets of the Evolutionary Turnover of this Coding Minisatellite
af: Jérôme Buard, et al.
Udgivet: (2014)

Distinct histone modifications define initiation and repair of meiotic recombination in the mouse
af: Buard, Jérôme, et al.
Udgivet: (2009)

Distinct histone modifications define initiation and repair of meiotic recombination in the mouse
af: Jérôme Buard, et al.
Udgivet: (2009)

High prevalence of PRDM9-independent recombination hotspots in placental mammals
af: Julien Joseph, et al.
Udgivet: (2024)

The PRDM9 KRAB domain is required for meiosis and involved in protein interactions
af: Imai, Yukiko, et al.
Udgivet: (2017)

The PRDM9 KRAB domain is required for meiosis and involved in protein interactions
af: Yukiko Imai, et al.
Udgivet: (2017)

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9
af: Hong Wu, et al.
Udgivet: (2013)

The complex binding of PRDM9
af: Ségurel, Laure
Udgivet: (2013)

Variability of PRDM9 in buffaloes
af: Leonardo Santana, et al.
Udgivet: (2025)

Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility
af: Flachs, Petr, et al.
Udgivet: (2012)

Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility
af: Petr Flachs, et al.
Udgivet: (2012)

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
af: Baker, Zachary, et al.
Udgivet: (2017)

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
af: Zachary Baker, et al.
Udgivet: (2017)

Pinpointing the PRDM9-PRDM7 Gene Duplication Event During Primate Divergence
af: Heerschop, Sacha, et al.
Udgivet: (2021)

Cataloging Human PRDM9 Allelic Variation Using Long-Read Sequencing Reveals PRDM9 Population Specificity and Two Distinct Groupings of Related Alleles
af: Alleva, Benjamin, et al.
Udgivet: (2021)

Discovery of a chemical probe for PRDM9
af: Abdellah Allali‐Hassani, et al.
Udgivet: (2019)

Discovery of a chemical probe for PRDM9
af: Allali-Hassani, Abdellah, et al.
Udgivet: (2019)

Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
af: Mihola, Ondrej, et al.
Udgivet: (2021)

High Diversity at PRDM9 in Chimpanzees and Bonobos
af: Groeneveld, Linn Fenna, et al.
Udgivet: (2012)

Characterization of Prdm9 in Equids and Sterility in Mules
af: Steiner, Cynthia C., et al.
Udgivet: (2013)

Primate evolution of the recombination regulator PRDM9
af: Schwartz, Jerrod J., et al.
Udgivet: (2014)

Interrogating the Functions of PRDM9 Domains in Meiosis
af: Thibault-Sennett, Sarah, et al.
Udgivet: (2018)

PRDM9 and its role in genetic recombination
af: Paigen, Kenneth, et al.
Udgivet: (2018)

PRDM9 and Its Role in Genetic Recombination
af: Kenneth Paigen, et al.
Udgivet: (2018)

Primate evolution of the recombination regulator PRDM9
af: Jerrod J. Schwartz, et al.
Udgivet: (2014)

Automation in genotyping of single nucleotide polymorphisms
af: Marta Gut
Udgivet: (2001)

DNA analysis by MALDI-TOF mass spectrometry
af: Marta Gut
Udgivet: (2004)

Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells
af: Tan, Shuang-Xiang, et al.
Udgivet: (2014)

Chromosome Organization in Early Meiotic Prophase
af: Grey, Corinne, et al.
Udgivet: (2021)