Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF may in addition radiosensitize tumor cells by targeting thioredoxin reductase (TrxR), a critical enzyme in the antioxida...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2017
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| 在线阅读: | https://doi.org/10.18632/oncotarget.16113 http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16113&path%5B%5D=51502 |
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