Purinergic Receptor Transactivation by the<i>β</i><sub>2</sub>-Adrenergic Receptor Increases Intracellular Ca<sup>2+</sup>in Nonexcitable Cells

Purinergic Receptor Transactivation by the<i>β</i><sub>2</sub>-Adrenergic Receptor Increases Intracellular Ca<sup>2+</sup>in Nonexcitable Cells

The β2 adrenergic receptor (β2AR) increases intracellular Ca2+ in a variety of cell types. By combining pharmacological and genetic manipulations, we reveal a novel mechanism through which the β2AR promotes Ca2+ mobilization (pEC50 = 7.32 ± 0.10) in nonexcitable human embryonic kidney (HEK)293S cell...

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Hlavní autoři: Wayne Stallaert, Emma T. van der Westhuizen, Anne-Marie Schönegge, Bianca Plouffe, Mireille Hogue, Viktoria Lukashova, Asuka Inoue, Satoru Ishida, Junken Aoki, Christian Le Gouill, Michel Bouvier
Médium: Artigo
Jazyk:angličtina
Vydáno: 2017
On-line přístup:https://doi.org/10.1124/mol.116.106419
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https://doi.org/10.1124/mol.116.106419

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