Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert glucose into fructose. Here we show the detrimental role of endogenous fructose production by the polyol pathway and its metabolism through fruct...
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| Hlavní autoři: | , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2017
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| On-line přístup: | https://doi.org/10.1038/ncomms14181 |
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